Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 12/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748373 | 1.00 | HDAC2 (0.63) | HDAC2HDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL8060005 | 1.00 | HDAC2 (0.63) | HDAC2HDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL3746746 | 1.00 | HDAC2 (0.63) | HDAC2HDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL3741827 | 0.86 | HDAC1 (0.55) | HDAC2HDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL2829700 | 0.86 | HDAC1 (0.55) | HDAC2HDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL8060566 | 0.86 | HDAC1 (0.55) | HDAC2HDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL2829702 | 0.86 | HDAC1 (0.55) | HDAC2HDAC3HDAC1HDAC8HDAC4 | |
| SCHEMBL23593943 | 0.81 | AKR1C1 (0.70) | HTT | |
| SCHEMBL6689798 | 0.81 | AKR1C1 (0.70) | HTT | |
| SCHEMBL2836206 | 0.81 | AKR1C1 (0.70) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450525-B2 | Histone deacetylase inhibitors | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2013-05-28 | — | — | US | claimed |
| US-20100291003-A1 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-11-18 | — | — | US | claimed |
| US-8450525-B2 | Histone deacetylase inhibitors | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2013-05-28 | — | — | US | disclosed |
| US-20100291003-A1 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100291003-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC5 | HDAC2 6/4885HDAC3 10/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.