Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 20/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 20/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 20/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796650 | 1.00 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3664315 | 1.00 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL1896068 | 1.00 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3665198 | 1.00 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL17455369 | 0.84 | SLC6A2 (0.83) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL17455205 | 0.84 | SLC6A2 (0.83) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL14738660 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL14739077 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3744776 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3669010 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507500-B2 | Inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-08-13 | — | — | US | disclosed |
| US-8440724-B2 | Inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| US-20130059864-A1 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-03-07 | — | — | US | disclosed |
| US-20100280127-A1 | INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2010-11-04 | — | — | US | disclosed |