Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CDC37 | Q16543 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 2/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517738 | 0.79 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1ERBB2MAP4K4ADORA2A | |
| SCHEMBL16486937 | 0.79 | ERBB2 (0.36) | HSP90AA1HSP90AB1ERBB2MAP4K4ADORA2A | |
| SCHEMBL3124057 | 0.77 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1ERBB2DHFR | |
| SCHEMBL3125128 | 0.77 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1ERBB2MAP4K4ADORA2A | |
| SCHEMBL3517145 | 0.76 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ERBB2ADORA2AADORA1 | |
| SCHEMBL3118790 | 0.76 | PRMT5 (0.40) | HSP90AA1HSP90AB1ERBB2MAP4K4ADORA2A | |
| SCHEMBL17771563 | 0.75 | SKP2 (0.37) | HSP90AA1HSP90AB1ERBB2ADORA2API4KA | |
| SCHEMBL3748288 | 0.74 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ERBB2ADORA2AADORA1 | |
| SCHEMBL3116014 | 0.73 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ERBB2 | |
| SCHEMBL1858420 | 0.73 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| WO-2009065035-A1 | THERAPEUTIC COMPOUNDS AND THEIR USE IN TREATING DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | VHL, CLN6, CFTR | HSP90AA1 659/4885HSP90AB1 501/4885ERBB2 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.