SCHEMBL375012

SCHEMBL375012

[CH]=CC#CCC

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL292227 0.75
SCHEMBL291164 0.69
SCHEMBL23624 0.69
SCHEMBL1741456 0.69
SCHEMBL15791944 0.67
SCHEMBL972050 0.67
SCHEMBL127175 0.67
SCHEMBL9158244 0.67
SCHEMBL2051368 0.67
SCHEMBL6487194 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043688-B2 Nickel catalysts with two alkali ions for homopolymerization and copolymerization UNIVERSITY OF HOUSTON SYSTEM (US) 2024-07-23 US disclosed
US-12043689-B2 Nickel catalysts with single metal cations for homopolymerization and copolymerization UNIVERSITY OF HOUSTON SYSTEM (US) 2024-07-23 US disclosed
EP-4374928-A2 NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING The Brigham And Women's Hospital Inc. (US) 2024-05-29 EP disclosed
US-20240166775-A1 NICKEL CATALYSTS WITH TWO METAL CATIONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION UNIVERSITY OF HOUSTON SYSTEM (US) 2024-05-23 US disclosed
WO-2024097972-A2 COMPOUNDS AND METHODS FOR TREATING CANCERS CEDARS-SINAI MEDICAL CENTER (US) 2024-05-10 WO disclosed
EP-3484474-B1 PHENOTHIAZINE COMPOUNDS FOR THE TREATMENT OF RIBOSOMAL DISORDERS AND RIBOSOMOPATHIES CHILDRENS MEDICAL CT CORP (US) 2024-05-08 EP disclosed
US-20240117076-A1 NICKEL CATALYSTS WITH SINGLE METAL CATIONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION UNIVERSITY OF HOUSTON SYSTEM (US) 2024-04-11 US disclosed
US-11944625-B2 Calmodulin inhibitors, Chk2 inhibitors and RSK inhibitors for the treatment of ribosomal disorders and ribosomapathies THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2024-04-02 US disclosed
US-20240101727-A1 NICKEL CATALYSTS WITH TWO ALKALI IONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION UNIVERSITY OF HOUSTON SYSTEM (US) 2024-03-28 US disclosed
US-20240101726-A1 NICKEL CATALYSTS WITH SINGLE ALKALI IONS FOR HOMOPOLYMERIZATION AND COPOLYMERIZATION UNIVERSITY OF HOUSTON SYSTEM (US) 2024-03-28 US disclosed
US-20020032175-A1 Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease VERTEX PHARMACEUTICALS INCORPORATED 2002-03-14 US disclosed
EP-0932617-B1 INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE VERTEX PHARMA (US) 2002-01-16 EP disclosed
EP-1136498-A1 Inhibitors of serine proteases, particularly hepatitis c virus NS3 protease Vertex Pharmaceuticals Incorporated (US) 2001-09-26 EP disclosed
US-6265380-B1 Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease VERTEX PHARMACEUTICALS INCORPORATED 2001-07-24 US disclosed
EP-1066247-A1 INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE Vertex Pharmaceuticals Incorporated (US) 2001-01-10 EP disclosed
CN-1238780-A Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease VERTEX PHARMA (US) 1999-12-15 CN disclosed
WO-1999050230-A1 INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE VERTEX PHARMACEUTICALS INCORPORATED (US) 1999-10-07 WO disclosed
EP-0932617-A1 INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE Vertex Pharmaceuticals Incorporated (US) 1999-08-04 EP disclosed
WO-1998017679-A1 INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE VERTEX PHARMACEUTICALS INCORPORATED (US) 1998-04-30 WO disclosed
US-5003089-A Preparation of cyclic 6-membered to 8-membered vinylene-1,2-dioxy compounds BASF AKTIENGESELLSCHAFT (DE) 1991-03-26 US disclosed