Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.68 |
| ▸ | MET | P08581 | 5/20 | 0.67 |
| ▸ | AURKA | O14965 | 4/20 | 0.67 |
| ▸ | TEK | Q02763 | 4/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758634 | 0.93 | KDR (0.71) | KDRMETAURKATEKAURKB | |
| SCHEMBL3757415 | 0.91 | KDR (0.69) | KDRMETAURKATEKAURKB | |
| SCHEMBL3754142 | 0.90 | KDR (0.68) | KDRMETAURKATEKAURKB | |
| SCHEMBL3751773 | 0.90 | KDR (0.78) | KDRMETAURKATEKAURKB | |
| SCHEMBL3755654 | 0.90 | KDR (0.61) | KDRMETAURKATEKAURKB | |
| SCHEMBL3760267 | 0.90 | KDR (0.72) | KDRMETAURKATEKAURKB | |
| SCHEMBL3758572 | 0.90 | KDR (0.65) | KDRMETAURKATEKAURKB | |
| SCHEMBL7783938 | 0.88 | KDR (0.59) | KDRMETAURKATEKAURKB | |
| SCHEMBL3759699 | 0.88 | KDR (0.79) | KDRMETAURKATEKAURKB | |
| SCHEMBL2746953 | 0.83 | KDR (0.85) | KDRMETAURKATEKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117377492-A | Pharmaceutical composition containing protein kinase inhibitor and medical application thereof | 深圳微芯生物科技股份有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-117377492-A | Pharmaceutical composition containing protein kinase inhibitor and medical application thereof | 深圳微芯生物科技股份有限公司 | 2024-01-09 | — | — | CN | disclosed |
| US-8211901-B2 | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-07-03 | — | — | US | disclosed |
| US-8211901-B2 | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-07-03 | — | — | US | disclosed |
| US-8211901-B2 | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-07-03 | — | — | US | disclosed |
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2010-11-25 | — | — | US | disclosed |
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2010-11-25 | — | — | US | disclosed |
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | HDAC1, HDAC2, HDAC5 | KDR 2729/4885MET 2038/4885AURKA 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.