Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | QRFPR | Q96P65 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755048 | 0.91 | PIK3CA (0.57) | PIK3CACREBBP | |
| SCHEMBL3757192 | 0.86 | PIK3CA (0.64) | PIK3CACREBBP | |
| SCHEMBL3749904 | 0.85 | PIK3CA (0.56) | PIK3CACREBBP | |
| SCHEMBL3756807 | 0.84 | PIK3CA (0.55) | PIK3CACREBBPMEN1KMT2A | |
| SCHEMBL3747619 | 0.84 | PIK3CA (0.57) | PIK3CACREBBP | |
| SCHEMBL3756363 | 0.84 | PIK3CA (0.65) | PIK3CACREBBP | |
| SCHEMBL3754440 | 0.83 | PIK3CA (0.60) | PIK3CACREBBP | |
| SCHEMBL3762451 | 0.83 | PIK3CA (0.60) | PIK3CACREBBP | |
| SCHEMBL3754841 | 0.83 | PIK3CA (0.61) | PIK3CACREBBP | |
| SCHEMBL12997188 | 0.82 | PIK3CA (0.47) | PIK3CACREBBPAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | EXELIXIS, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | EXELIXIS, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | EXELIXIS, INC. (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | MTOR, RICTOR, RPTOR | PIK3CA 16/4885KCNH2 4697/4885QRFPR 4249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.