Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.65 |
| ▸ | NCOR2 | Q9Y618 | 11/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28789405 | 0.88 | HDAC1 (0.58) | HDAC1HDAC3NCOR2HDAC2HDAC6 | |
| SCHEMBL15551664 | 0.88 | HDAC1 (1.00) | HDAC1HDAC3NCOR2HDAC2HDAC8 | |
| SCHEMBL8241099 | 0.87 | HDAC1 (0.76) | HDAC1HDAC3NCOR2HDAC2HDAC8 | |
| SCHEMBL26775744 | 0.86 | HDAC1 (0.90) | HDAC1HDAC3NCOR2HDAC2HDAC8 | |
| SCHEMBL24972905 | 0.84 | HDAC1 (0.85) | HDAC1HDAC3NCOR2HDAC2HDAC8 | |
| SCHEMBL3758034 | 0.83 | PTGS1 (0.58) | HDAC1HDAC3NCOR2HDAC2HDAC6 | |
| SCHEMBL3762395 | 0.83 | HDAC1 (0.53) | HDAC1HDAC3NCOR2HDAC2HDAC8 | |
| SCHEMBL24890740 | 0.83 | HDAC1 (0.68) | HDAC1HDAC3NCOR2HDAC2HDAC8 | |
| SCHEMBL16886014 | 0.82 | HDAC1 (0.82) | HDAC1HDAC3NCOR2HDAC2HDAC8 | |
| SCHEMBL15553332 | 0.82 | HDAC1 (1.00) | HDAC1HDAC3NCOR2HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101906076-B | Naphthaline amide derivative serving as protein kinase inhibitor and histone deacetylase inhibitor and preparation method and application thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2013-03-13 | — | — | CN | disclosed |
| US-8211901-B2 | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-07-03 | — | — | US | disclosed |
| US-8211901-B2 | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-07-03 | — | — | US | disclosed |
| US-8211901-B2 | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-07-03 | — | — | US | disclosed |
| CN-101906076-A | Naphthaline amide derivative serving as protein kinase inhibitor and histone deacetylase inhibitor and preparation method and application thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2010-12-08 | — | — | CN | disclosed |
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2010-11-25 | — | — | US | disclosed |
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2010-11-25 | — | — | US | disclosed |
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | HDAC1, HDAC2, HDAC5 | HDAC1 1/4885HDAC3 7/4885NCOR2 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.