Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NSD2 | O96028 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | CASP7 | P55210 | 1/20 | 0.63 |
| ▸ | CASP6 | P55212 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LGMN | Q99538 | 2/20 | 0.45 |
| ▸ | PRKDC | P78527 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750968 | 0.87 | MAPT (0.63) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL1514606 | 0.85 | TDP1 (0.45) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL16404654 | 0.83 | TDP1 (0.44) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2450403 | 0.81 | MAPT (0.63) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL3320628 | 0.77 | MAPT (0.63) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL1237566 | 0.77 | KDM4E (0.63) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL81970 | 0.77 | MAPT (0.63) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL6687266 | 0.75 | MAPT (0.64) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10274764 | 0.75 | RAD51 (0.63) | MAPTHTTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL7928249 | 0.75 | MEN1 (0.52) | MAPTHTTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586952-B2 | Polycyclic estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9586952-B2 | Polycyclic estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9586952-B2 | Polycyclic estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160355508-A1 | POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-12-08 | — | — | US | disclosed |
| US-20160355508-A1 | POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-12-08 | — | — | US | disclosed |
| US-20160355508-A1 | POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-12-08 | — | — | US | disclosed |
| EP-2970130-A1 | POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | Seragon Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2678315-B1 | (Pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nAChR | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-16 | — | — | EP | disclosed |
| CN-105121413-A | Polycyclic estrogen receptor modulators and uses thereof | SERAGON PHARMACEUTICALS INC | 2015-12-02 | — | — | CN | disclosed |
| US-20150232429-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE | 2015-08-20 | — | — | US | disclosed |
| US-20130231336-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231336-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231336-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-09-05 | — | — | US | disclosed |
| WO-2012113850-A2 | (PYRIDIN-4-YL)BENZYLAMIDES AS ALLOSTERIC MODULATORS OF ALPHA 7 nAChR | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-30 | — | — | WO | disclosed |
| US-20100298312-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100298312-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100298312-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-11-25 | — | — | US | disclosed |
| EP-2200436-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231336-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K5, MAP3K7 | MAPT 1055/4885HTT 3261/4885KDM4E 2345/4885 |
| US-20100298312-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K5, MAP3K7 | MAPT 1055/4885HTT 3261/4885KDM4E 2345/4885 |
| US-20150232429-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K5, MAP3K7 | MAPT 1055/4885HTT 3261/4885KDM4E 2345/4885 |
| US-20160355508-A1 | POLYCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ESR2, ESRRG, GPER1 | MAPT 4021/4885HTT 4343/4885KDM4E 2703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.