Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4797081 | 0.88 | CKS1B (0.37) | PDCD1CD274HTR2CMTNR1AMTNR1B | |
| SCHEMBL3154917 | 0.79 | ACACB (0.38) | KCNH2DRD2 | |
| SCHEMBL3149200 | 0.79 | ACACB (0.38) | KCNH2DRD2 | |
| SCHEMBL1083619 | 0.78 | KCNH2 (0.43) | PDCD1CD274KCNH2SLC2A1 | |
| SCHEMBL1267140 | 0.78 | KCNH2 (0.43) | PDCD1CD274KCNH2SLC2A1 | |
| SCHEMBL3144806 | 0.78 | SLC2A1 (0.33) | HTR2CMTNR1AMTNR1BKCNH2SLC2A1 | |
| SCHEMBL3158168 | 0.77 | SLC2A1 (0.36) | HTR2CMTNR1AMTNR1BKCNH2SLC2A1 | |
| SCHEMBL3158158 | 0.77 | SLC2A1 (0.36) | HTR2CMTNR1AMTNR1BKCNH2SLC2A1 | |
| SCHEMBL1036797 | 0.77 | SLC2A1 (0.42) | HTR2CMTNR1AMTNR1BKCNH2SLC2A1 | |
| SCHEMBL1082893 | 0.76 | KCNH2 (0.37) | HTR2CMTNR1AMTNR1BKCNH2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176262-A1 | TRICYCLIC COMPOUNDS AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2010-04-21 | — | — | EP | disclosed |
| WO-2008128962-A1 | TRICYCLIC COMPOUNDS AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |