SCHEMBL3754662

SCHEMBL3754662

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)OS(=O)(=O)O

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.55
KCNH2 Q12809 1/20 0.55
VNN1 O95497 13/20 0.49
ZDHHC20 Q5W0Z9 1/20 0.34
CA12 O43570 1/20 0.30
CA14 Q9ULX7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29250117 0.99 PTGS1 (0.54) PTGS1KCNH2VNN1ZDHHC20
SCHEMBL8039883 0.99 PTGS1 (0.54) PTGS1KCNH2VNN1ZDHHC20
SCHEMBL28332287 0.97 PTGS1 (0.52) PTGS1KCNH2VNN1ZDHHC20
SCHEMBL28416351 0.85 PTGS1 (0.51) PTGS1KCNH2VNN1ZDHHC20
SCHEMBL28416349 0.85 PTGS1 (0.51) PTGS1KCNH2VNN1ZDHHC20
SCHEMBL10932748 0.83 PTGS1 (0.63) PTGS1KCNH2VNN1CA12CA14
SCHEMBL7016637 0.83 PTGS1 (0.63) PTGS1KCNH2VNN1ZDHHC20
SCHEMBL7524751 0.83 PTGS1 (0.63) PTGS1KCNH2VNN1CA12CA14
SCHEMBL7524756 0.83 PTGS1 (0.63) PTGS1KCNH2VNN1CA12CA14
SCHEMBL2458620 0.82 PTGS1 (0.61) PTGS1KCNH2VNN1ZDHHC20

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8252753-B2 Oligonucleotide and the use thereof for modulating an isoform C beta-1 protein-kinase in the form of a skin depigmentation agent L V M H RECHERCHE (FR) 2012-08-28 US claimed
EP-1699923-B1 OLIGONUCLEOTIDE AND THE USE THEREOF FOR MODULATING AN ISOFORM C BETA-1 PROTEIN-KINASE IN THE FORM OF A SKIN DEPIGMENTATION AGENT LVMH RECH (FR) 2008-07-30 EP claimed
JP-4056743-B2 2008-03-05 JP claimed
US-20070274936-A1 Oligonucleotide and the Use Thereof for Modulating an Isoform C Beta-1 Protein-Kinase in the Form of a Skin Depigmentation Agent L V M H RECHERCHE (FR) 2007-11-29 US claimed
JP-2007516715-A 2007-06-28 JP claimed
EP-1699923-A2 OLIGONUCLEOTIDE AND THE USE THEREOF FOR MODULATING AN ISOFORM C BETA-1 PROTEIN-KINASE IN THE FORM OF A SKIN DEPIGMENTATION AGENT L V M H RECHERCHE (FR) 2006-09-13 EP claimed
WO-2005073243-A2 OLIGONUCLEOTIDE AND THE USE THEREOF FOR MODULATING AN ISOFORM C BETA-1 PROTEIN-KINASE IN THE FORM OF A SKIN DEPIGMENTATION AGENT L V M H RECHERCHE (FR) 2005-08-11 WO claimed
JP-2003521929-A 2003-07-22 JP claimed
EP-1255827-A2 NOVEL OLIGONUCLEOTIDES AND USE OF OLIGONUCLEOTIDES MODULATING THE EXPRESSION OF ENZYMES INVOLVED IN THE SYNTHESIS OF MELANIC PIGMENTS, AS DEPIGMENTATION AGENTS LVMH RECHERCHE (FR) 2002-11-13 EP claimed
WO-2001058918-A2 OLIGONUCLEOTIDES MODULATING THE EXPRESSION OF ENZYMES INVOLVED IN THE SYNTHESIS OF MELANIC PIGMENTS LVMH RECHERCHE (FR) 2001-08-16 WO claimed
CN-111000773-A Preparation method of pholiota nameko mucilage and skin care product and beauty food prepared from pholiota nameko mucilage 周伦辉 2020-04-14 CN disclosed
EP-2935587-B1 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF TYROSINASE LVMH RECH (FR) 2018-03-14 EP disclosed
US-9732348-B2 Aptamers inhibiting the enzymatic activity of tyrosinase L V M H Recherché (FR) 2017-08-15 US disclosed
CN-105264075-A Aptamers inhibiting the enzymatic activity of tyrosinase LVMH RECH 2016-01-20 CN disclosed
US-20150329863-A1 APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF TYROSINASE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2015-11-19 US disclosed
WO-2007026009-A1 NOVEL TYROSINASE-SPECIFIC ANTIGENIC OLIGONUCLEOTIDES AS DEPIGMENTING AGENTS L V M H RECHERCHE (FR) 2007-03-08 WO disclosed
EP-1699923-A2 OLIGONUCLEOTIDE AND THE USE THEREOF FOR MODULATING AN ISOFORM C BETA-1 PROTEIN-KINASE IN THE FORM OF A SKIN DEPIGMENTATION AGENT L V M H RECHERCHE (FR) 2006-09-13 EP disclosed
WO-2005073243-A2 OLIGONUCLEOTIDE AND THE USE THEREOF FOR MODULATING AN ISOFORM C BETA-1 PROTEIN-KINASE IN THE FORM OF A SKIN DEPIGMENTATION AGENT L V M H RECHERCHE (FR) 2005-08-11 WO disclosed
EP-1255827-A2 NOVEL OLIGONUCLEOTIDES AND USE OF OLIGONUCLEOTIDES MODULATING THE EXPRESSION OF ENZYMES INVOLVED IN THE SYNTHESIS OF MELANIC PIGMENTS, AS DEPIGMENTATION AGENTS LVMH RECHERCHE (FR) 2002-11-13 EP disclosed
WO-2001058918-A2 OLIGONUCLEOTIDES MODULATING THE EXPRESSION OF ENZYMES INVOLVED IN THE SYNTHESIS OF MELANIC PIGMENTS LVMH RECHERCHE (FR) 2001-08-16 WO disclosed