Sugi Predict

Sugi Predict / Compounds / SCHEMBL3755596

SCHEMBL3755596

SCHEMBL3755596

COc1ccc(CNc2ncnc3c2cnn3-c2cccc(C)c2)cc1OC

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 15/20 0.73
▸ ALDH1A1 P00352 9/20 0.73
▸ HSD17B10 Q99714 8/20 0.73
▸ HPGD P15428 8/20 0.73
▸ LMNA P02545 8/20 0.73
▸ SMN1; SMN2 Q16637 7/20 0.73
▸ MEN1 O00255 6/20 0.73
▸ KMT2A Q03164 6/20 0.73
▸ NPSR1 Q6W5P4 3/20 0.73
▸ MAPT P10636 9/20 0.71
▸ HTT P42858 4/20 0.71
▸ RAB9A P51151 8/20 0.68
▸ NPC1 O15118 6/20 0.68
▸ MAPK1 P28482 3/20 0.68
▸ TSHR P16473 2/20 0.68
▸ POLB P06746 1/20 0.68
▸ EGFR P00533 1/20 0.68
▸ MAPK10 P53779 1/20 0.63
▸ PIP4K2A P48426 1/20 0.62
▸ KCNK2 O95069 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3763448 0.91 MAPT (0.61) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL3757527 0.90 KDM4E (0.73) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL3765042 0.90 KDM4E (0.58) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL13058259 0.90 KDM4E (0.72) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL3757355 0.89 KDM4E (0.68) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL3759099 0.88 KDM4E (0.79) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL3425995 0.87 KDM4E (0.55) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL13058221 0.87 KDM4E (0.55) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL3758966 0.86 KDM4E (0.67) KDM4EALDH1A1HSD17B10HPGDLMNA
SCHEMBL3766548 0.86 KDM4E (0.54) KDM4EALDH1A1HSD17B10HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US claimed
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS NATCO PHARMA LIMITED (IN) 2010-11-25 — — US claimed
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US disclosed
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US disclosed
US-8349847-B2 Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents KONAKANCHI DURGA PRASAD (IN) 2013-01-08 — — US disclosed
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS NATCO PHARMA LIMITED (IN) 2010-11-25 — — US disclosed
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS NATCO PHARMA LIMITED (IN) 2010-11-25 — — US disclosed
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS NATCO PHARMA LIMITED (IN) 2010-11-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298351-A1 NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS DPYD, TYMP, TYMS KDM4E 1866/4885ALDH1A1 309/4885HSD17B10 4410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.