⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL227850 | 0.79 | CYP3A4 (0.34) | — | |
| SCHEMBL736531 | 0.71 | — | — | |
| SCHEMBL19199690 | 0.69 | — | — | |
| SCHEMBL3853920 | 0.69 | — | — | |
| SCHEMBL172997 | 0.69 | CYP3A4 (0.31) | — | |
| SCHEMBL2272593 | 0.69 | — | — | |
| SCHEMBL17975839 | 0.69 | — | — | |
| SCHEMBL363890 | 0.69 | — | — | |
| SCHEMBL16387894 | 0.69 | — | — | |
| SCHEMBL1620302 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950848-A | Synthesis and application of novel amino pyrazole derivatives | 徐诺药业 | 2020-04-03 | — | — | CN | claimed |
| US-8921424-B2 | Histone deacetylase inhibitors, process for preparation and uses thereof | ZHEJIANG HISUN PHARMACEUTICAL CO. LTD. (CN) | 2014-12-30 | — | — | US | claimed |
| EP-2208721-B1 | HISTONE DEACETYLASE INHIBITOR, COMPOSITION AND USE THEREOF | ZHEJIANG HISUN PHARM CO LTD (CN) | 2013-12-25 | — | — | EP | claimed |
| EP-2287156-B1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-05-29 | — | — | EP | claimed |
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | claimed |
| US-20110218221-A1 | NOVEL HISTONE DEACETYLASE INHIBITORS, PROCESS FOR PREPARATION AND USES THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2011-09-08 | — | — | US | claimed |
| US-20110098280-A1 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2011-04-28 | — | — | US | claimed |
| EP-2287156-A1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | Novartis AG (CH) | 2011-02-23 | — | — | EP | claimed |
| US-7893074-B2 | inhibition of focal adhesion kinase or/and IGF-1 Receptor; for example: 2-[2-(2,5-Dimethoxy-phenylamino)-5-nitro-pyrimidin-4-ylamino]-N-methyl-benzenesulfonamide | NOVARTIS AG (CH) | 2011-02-22 | — | — | US | claimed |
| EP-2208721-A1 | HISTONE DEACETYLASE INHIBITOR, COMPOSITION AND USE THEREOF | Zhejiang Hisun Pharmaceutical Co. Ltd. (CN) | 2010-07-21 | — | — | EP | claimed |
| WO-2005016894-A1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2005-02-24 | — | — | WO | claimed |
| US-6846827-B1 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-01-25 | — | — | US | claimed |
| EP-1226126-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-01-05 | — | — | EP | claimed |
| EP-1226126-A1 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-31 | — | — | EP | claimed |
| US-20020058788-A1 | Facile deprotection of Fmoc protected amino groups | DISCOVERY PARTNERS INTERNATIONAL, INC. | 2002-05-16 | — | — | US | claimed |
| WO-2001027089-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-04-19 | — | — | WO | claimed |
| EP-0025109-B1 | 1-BENZOXEPIN-5(2H)-ONE DERIVATIVES AND THEIR SALTS, AND PROCESSES FOR THEIR PREPARATION | Kali-Chemie Pharma GmbH (DE) | 1985-05-15 | — | — | EP | claimed |
| EP-0024560-B1 | 3-AMINO-1-BENZOXEPINE DERIVATIVES AND THEIR SALTS, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Kali-Chemie Pharma GmbH (DE) | 1983-04-13 | — | — | EP | claimed |
| US-4279904-A | GASTROINTESTINAL DISORDERS | KALI-CHEMIE PHARMA GMBH (DE) | 1981-07-21 | — | — | US | claimed |
| US-4279905-A | GASTROINTESTINAL DISORDERS | KALI-CHEMIE PHARMA GMBH (DE) | 1981-07-21 | — | — | US | claimed |