Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | MARK3 | P27448 | 8/20 | 0.53 |
| ▸ | KDR | P35968 | 10/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3763056 | 0.89 | MKNK1 (0.58) | MAP4K4CHEK1MARK3KDRFLT1 | |
| SCHEMBL3761556 | 0.87 | MARK3 (0.53) | CHEK1MARK3KDRFLT1FLT4 | |
| SCHEMBL5416682 | 0.86 | KDR (0.67) | MAP4K4KDRFLT1FLT4PRKAB1 | |
| SCHEMBL3758779 | 0.84 | MARK3 (0.53) | CHEK1MARK3KDRFLT1FLT4 | |
| SCHEMBL3762618 | 0.83 | CCNC (0.58) | CHEK1MARK3KDRPRKAB1SGK1 | |
| SCHEMBL13126019 | 0.83 | KDR (0.76) | MAP4K4MARK3KDRFLT1FLT4 | |
| SCHEMBL3761581 | 0.81 | MARK3 (0.56) | CHEK1MARK3KDRPRKAB1SGK1 | |
| SCHEMBL3766798 | 0.81 | MARK3 (0.57) | CHEK1MARK3KDRFLT1FLT4 | |
| SCHEMBL3767614 | 0.81 | MARK3 (0.56) | CHEK1MARK3KDRPRKAB1SGK1 | |
| SCHEMBL1222255 | 0.81 | CHEK1 (0.70) | MAP4K4CHEK1METPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178375-B1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME (US) | 2014-09-24 | — | — | EP | disclosed |
| US-8461162-B2 | Pyrazolo[1,5-a]pyrimidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME LLC | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MAPT, TTBK1, TTBK2 | MAP4K4 55/4885CHEK1 329/4885MARK3 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.