Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.40 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | OPA1 | O60313 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | STK16 | O75716 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765560 | 0.91 | BUB1 (0.40) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL3757673 | 0.88 | PIK3CA (0.41) | SCN9APRKDCNPC1RAB9APIK3CD | |
| SCHEMBL3759936 | 0.88 | CYP2C19 (0.49) | CAMK2DCYP2C9CYP2C19 | |
| SCHEMBL3764646 | 0.88 | MAPK1 (0.47) | JAK2HDAC1JAK1TYK2SCN9A | |
| SCHEMBL3761437 | 0.86 | PRMT5 (0.41) | ROCK2ROCK1L3MBTL1NPC1 | |
| SCHEMBL3762516 | 0.86 | MEN1 (0.46) | HDAC1ROCK2ROCK1KDM1APIK3CA | |
| SCHEMBL3759832 | 0.86 | PRKDC (0.39) | PRKD1SCN9APRKDCNPC1RAB9A | |
| SCHEMBL3760529 | 0.85 | PRKDC (0.47) | SCN9APRKDCNPC1RAB9APIK3CD | |
| SCHEMBL3754752 | 0.85 | PRKDC (0.45) | SCN9APRKDCNPC1RAB9APIK3CD | |
| SCHEMBL3761666 | 0.85 | KMT2A (0.48) | HDAC1SCN9AL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-B1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-10-15 | — | — | EP | disclosed |
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | JAK2 128/4885PRKD1 543/4885CTSL 4214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.