Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 10/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3759747 | 0.83 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL3760022 | 0.80 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL3751895 | 0.80 | PIK3CA (0.40) | KMT2APIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3765049 | 0.79 | POLB (0.35) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL3763646 | 0.79 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGPDE4B | |
| SCHEMBL3764957 | 0.78 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL3759332 | 0.78 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGPDE4B | |
| SCHEMBL3754871 | 0.78 | PIK3CA (0.43) | CYP2C9CYP2C19PIK3CAPIK3CDPIK3CB | |
| SCHEMBL3766673 | 0.77 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL3762269 | 0.76 | PIK3CA (0.35) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | ABL1 530/4885LMNA 4870/4885CYP2C9 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.