Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.64 |
| ▸ | PLK1 | P53350 | 13/20 | 0.64 |
| ▸ | PLK3 | Q9H4B4 | 7/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.64 |
| ▸ | TAF1 | P21675 | 5/20 | 0.64 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.64 |
| ▸ | CLK2 | P49760 | 3/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.64 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.64 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.64 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.64 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.64 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.64 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | FES | P07332 | 2/20 | 0.64 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375831 | 0.91 | PLK1 (0.72) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL375834 | 0.88 | PLK1 (0.69) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL375990 | 0.87 | PLK1 (0.63) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL13260921 | 0.87 | PLK1 (0.63) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL13227865 | 0.87 | PLK1 (0.63) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL12360946 | 0.86 | PLK1 (0.77) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL375991 | 0.85 | BRD4 (0.65) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL375992 | 0.85 | PLK1 (0.64) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL13542019 | 0.85 | PLK1 (0.79) | BRD4PLK1PLK3ALKTAF1 | |
| SCHEMBL376661 | 0.85 | PLK1 (0.70) | BRD4PLK1PLK3ALKTAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |