Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 3/20 | 0.38 |
| ▸ | PRKACG | P22612 | 3/20 | 0.38 |
| ▸ | PRKACB | P22694 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755059 | 1.00 | PRKACA (0.38) | PRKACAPRKACGPRKACBKDM1AMAPKAPK2 | |
| SCHEMBL3754902 | 0.96 | PSMB8 (0.35) | PRKACAPRKACGPRKACBMAPKAPK2PSMB8 | |
| SCHEMBL3763610 | 0.92 | MTOR (0.40) | MAPKAPK2PSMB8MTORBUB1LRRK2 | |
| SCHEMBL3760623 | 0.91 | PSMB8 (0.41) | MAPKAPK2PSMB8BUB1LRRK2PIK3CA | |
| SCHEMBL16161763 | 0.90 | MAPKAPK2 (0.34) | MAPKAPK2PSMB8BUB1PIK3CAPIK3CD | |
| SCHEMBL3762537 | 0.89 | PRKACA (0.41) | PRKACAPRKACGPRKACBKDM1APSMB8 | |
| SCHEMBL3760242 | 0.89 | PSMB8 (0.38) | MAPKAPK2PSMB8MTORBUB1LRRK2 | |
| SCHEMBL3760629 | 0.89 | MAPKAPK2 (0.34) | MAPKAPK2PSMB8BUB1LRRK2PIK3CA | |
| SCHEMBL3760485 | 0.89 | MAPKAPK2 (0.36) | MAPKAPK2PSMB8MTORBUB1LRRK2 | |
| SCHEMBL3751951 | 0.89 | PIK3CA (0.36) | MAPKAPK2PSMB8MTORBUB1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-B1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-10-15 | — | — | EP | disclosed |
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | PRKACA 155/4885PRKACG 197/4885PRKACB 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.