Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.33 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8594756 | 0.93 | PIK3CA (0.35) | PIK3CACREBBPGPR142MTOR | |
| SCHEMBL13057043 | 0.92 | CLK1 (0.34) | PIK3CACREBBPGPR142PIK3CDPIK3CB | |
| SCHEMBL3716278 | 0.92 | PIK3CA (0.40) | PIK3CACREBBPGPR142PIK3CG | |
| SCHEMBL856191 | 0.89 | PIK3CA (0.32) | PIK3CAKIT | |
| SCHEMBL861994 | 0.89 | PIK3CA (0.37) | PIK3CACREBBPKITPIK3CDPIK3CB | |
| SCHEMBL3760157 | 0.88 | PIK3CA (0.34) | PIK3CACREBBPGPR142KITPIK3CD | |
| SCHEMBL3716219 | 0.88 | PIK3CA (0.33) | PIK3CACREBBPGPR142 | |
| SCHEMBL15522787 | 0.87 | PIK3CA (0.35) | PIK3CACREBBPGPR142MTOR | |
| SCHEMBL859319 | 0.86 | PIK3CA (0.34) | PIK3CACREBBPKITPIK3CDPIK3CB | |
| SCHEMBL3760465 | 0.86 | PIK3CA (0.35) | PIK3CACREBBPGPR142MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648066-B2 | Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture | EXELIXIS, INC. (US) | 2014-02-11 | — | — | US | claimed |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8648066-B2 | Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture | EXELIXIS, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | EXELIXIS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298290-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | PIK3CA 3/4885CREBBP 259/4885GPR142 1660/4885 |
| US-20140080810-A1 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3CA | PIK3CA 3/4885CREBBP 257/4885GPR142 2004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.