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SCHEMBL3760947

SCHEMBL3760947

CNC(=O)c1cccc(-c2cnn3c(-c4ccnc(-c5ccc(F)cc5)c4)cnc3c2)c1.CNC(=O)c1cccc(-c2cnn3c(-c4ccnc(-c5ccco5)c4)cnc3c2)c1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FGFR3 P22607 11/20 0.57
▸ FGFR1 P11362 9/20 0.57
▸ FYN P06241 7/20 0.47
▸ FLT3 P36888 3/20 0.44
▸ NTRK1 P04629 2/20 0.44
▸ PDGFRB P09619 2/20 0.44
▸ KIT P10721 2/20 0.44
▸ ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL836782 0.93 FGFR1 (0.65) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL835499 0.93 FGFR3 (0.66) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL837301 0.86 FGFR3 (0.67) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL834829 0.85 FGFR1 (0.70) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL836186 0.81 FGFR1 (0.65) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL2347266 0.81 FGFR1 (0.64) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL835840 0.80 FGFR3 (0.73) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL3033485 0.80 FGFR3 (0.56) FGFR3FGFR1FYNFLT3ATM
SCHEMBL837206 0.78 FGFR3 (0.70) FGFR3FGFR1FYNFLT3NTRK1
SCHEMBL2340954 0.75 FGFR3 (0.66) FGFR3FGFR1FYNFLT3NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2183027-A1 ORGANIC COMPOUNDS Novartis Ag (CH) 2010-05-12 — — EP claimed
WO-2009013335-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2009-01-29 — — WO claimed