Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12584014 | 1.00 | IRAK4 (0.58) | IRAK4MKNK1MKNK2AURKAAURKB | |
| SCHEMBL10238519 | 0.94 | IRAK4 (0.66) | IRAK4MKNK1MKNK2AURKAAURKB | |
| SCHEMBL14514057 | 0.87 | IRAK4 (0.58) | IRAK4MKNK1MKNK2AURKAAURKB | |
| SCHEMBL10239085 | 0.84 | IRAK4 (0.62) | IRAK4MKNK1MKNK2AURKAAURKB | |
| SCHEMBL10239851 | 0.84 | IRAK4 (0.62) | IRAK4MKNK1MKNK2 | |
| SCHEMBL10239086 | 0.83 | IRAK4 (0.52) | IRAK4MKNK1MKNK2AURKAAURKB | |
| SCHEMBL10238538 | 0.83 | IRAK4 (0.44) | IRAK4MKNK1MKNK2AURKAAURKB | |
| SCHEMBL10239114 | 0.83 | IRAK4 (0.45) | IRAK4MKNK1MKNK2 | |
| SCHEMBL10239520 | 0.83 | IRAK4 (0.45) | IRAK4MKNK1MKNK2 | |
| SCHEMBL10238390 | 0.83 | IRAK4 (0.44) | IRAK4MKNK1MKNK2MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518952-B2 | 6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors | PFIZER INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20110144084-A1 | 6 SUBSTITUTED 2- HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110144084-A1 | 6 SUBSTITUTED 2- HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144084-A1 | 6 SUBSTITUTED 2- HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | CHKA, CSNK1A1, CHKB | IRAK4 816/4885MKNK1 65/4885MKNK2 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.