Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.69 |
| ▸ | PLK3 | Q9H4B4 | 14/20 | 0.69 |
| ▸ | PLK2 | Q9NYY3 | 14/20 | 0.69 |
| ▸ | BRD4 | O60885 | 5/20 | 0.65 |
| ▸ | TAF1 | P21675 | 1/20 | 0.65 |
| ▸ | PARP1 | P09874 | 2/20 | 0.60 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376078 | 0.90 | PLK1 (0.64) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL3779666 | 0.88 | PLK1 (0.61) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376162 | 0.88 | PLK1 (0.65) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376189 | 0.87 | PLK1 (0.64) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376190 | 0.87 | PLK1 (0.64) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376050 | 0.86 | PLK1 (0.71) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL17507106 | 0.86 | BRD4 (0.76) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL17507107 | 0.86 | BRD4 (0.76) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376761 | 0.85 | BRD4 (0.62) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376015 | 0.84 | PLK1 (0.77) | PLK1PLK3PLK2BRD4TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |