Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479100 | 0.87 | CYP3A4 (0.61) | CYP3A4CRBN | |
| Water SCHEMBL2484221 | 0.86 | CYP3A4 (0.60) | CYP3A4CRBN | |
| Water SCHEMBL2908232 | 0.85 | CYP3A4 (0.59) | CYP3A4CRBN | |
| SCHEMBL1530243 | 0.83 | CRBN (0.60) | CYP3A4CRBNFABP4FABP5WDR5 | |
| SCHEMBL1530238 | 0.83 | CRBN (0.60) | CYP3A4CRBNFABP4FABP5WDR5 | |
| SCHEMBL2111470 | 0.81 | CRBN (0.42) | CYP3A4CRBNFABP4FABP5KDM4E | |
| SCHEMBL2111469 | 0.81 | CRBN (0.42) | CYP3A4CRBNFABP4FABP5KDM4E | |
| SCHEMBL2712526 | 0.80 | CYP3A4 (0.42) | CYP3A4CRBNFABP4FABP5WDR5 | |
| SCHEMBL2712525 | 0.80 | CYP3A4 (0.42) | CYP3A4CRBNFABP4FABP5WDR5 | |
| SCHEMBL2913914 | 0.80 | CRBN (0.42) | CYP3A4CRBNKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203430-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | Abbott Laboratories (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009039135-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |