Sugi Predict

Sugi Predict / Compounds / SCHEMBL3764849

SCHEMBL3764849

SCHEMBL3764849

CC(C)(C(=O)O)c1ccc(-c2c[nH]c3ncc(-c4cccc(C(N)=O)c4)cc23)cc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SGK1 O00141 6/20 0.80
▸ AXL P30530 6/20 0.78
▸ CDC7 O00311 1/20 0.78
▸ PLK4 O00444 1/20 0.78
▸ CHEK1 O14757 1/20 0.78
▸ AURKA O14965 1/20 0.78
▸ MAPK13 O15264 1/20 0.78
▸ PDPK1 O15530 1/20 0.78
▸ DYRK3 O43781 1/20 0.78
▸ ROCK2 O75116 1/20 0.78
▸ RPS6KA5 O75582 1/20 0.78
▸ PRKD3 O94806 1/20 0.78
▸ PAK4 O96013 1/20 0.78
▸ CHEK2 O96017 1/20 0.78
▸ ABL1 P00519 1/20 0.78
▸ EGFR P00533 1/20 0.78
▸ NTRK1 P04629 1/20 0.78
▸ INSR P06213 1/20 0.78
▸ LCK P06239 1/20 0.78
▸ FYN P06241 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3761635 0.89 SGK1 (1.00) SGK1AXLCDC7PLK4CHEK1
SCHEMBL30368539 0.88 AXL (1.00) SGK1AXLCDC7PLK4CHEK1
SCHEMBL29004628 0.88 AXL (1.00) SGK1AXLCDC7PLK4CHEK1
SCHEMBL3770510 0.86 AXL (0.87) SGK1AXLCDC7PLK4CHEK1
SCHEMBL3763942 0.85 SGK1 (1.00) SGK1AXLCDC7PLK4CHEK1
SCHEMBL3763656 0.85 SGK1 (0.76) SGK1AXLCDC7PLK4CHEK1
SCHEMBL3765177 0.84 SGK1 (1.00) SGK1AXLCDC7PLK4CHEK1
SCHEMBL29004630 0.84 AXL (0.83) SGK1AXLCDC7PLK4CHEK1
SCHEMBL30368700 0.84 AXL (0.83) SGK1AXLCDC7PLK4CHEK1
SCHEMBL29004633 0.84 AXL (0.83) SGK1AXLCDC7PLK4CHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120238588-A1 1H-Pyrrolo[2,3-B]Pyridines GlaxoSmithKline, LLC 2012-09-20 — — US claimed
WO-2010049173-A1 USE OF INHIBITORS OF HOST KINASES FOR THE TREATMENT OF INFECTIOUS DISEASES CENIX BIOSCIENCE GMBH (DE) 2010-05-06 — — WO claimed
US-20090233955-A1 1H-Pyrrolo[2,3-B]Pyridnes GLAXOSMITHKLINE LLC 2009-09-17 — — US claimed
EP-1828180-A1 1H-PYRROLO[2,3-BETA]PYRIDINES SMITHKLINE BEECHAM CORPORATION (US) 2007-09-05 — — EP claimed
WO-2006063167-A1 1H-PYRROLO[2,3-B]PYRIDINES SMITHKLINE BEECHAM CORPORATION (US) 2006-06-15 — — WO claimed
WO-2021006707-A1 USE OF SGK1 INHIBITOR AS THERAPEUTIC AGENT FOR INFLAMMATORY NEUROLOGICAL DISEASES 한양대학교 산학협력단 2021-01-14 — — WO disclosed
US-20120238588-A1 1H-Pyrrolo[2,3-B]Pyridines GlaxoSmithKline, LLC 2012-09-20 — — US disclosed
US-20090233955-A1 1H-Pyrrolo[2,3-B]Pyridnes GLAXOSMITHKLINE LLC 2009-09-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090233955-A1 1H-Pyrrolo[2,3-B]Pyridnes SGK1, SGK2, SGK3 SGK1 1/4885AXL 1542/4885CDC7 634/4885
US-20120238588-A1 1H-Pyrrolo[2,3-B]Pyridines SGK1, SGK2, SGK3 SGK1 1/4885AXL 1432/4885CDC7 643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.