Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.46 |
| ▸ | JAK1 | P23458 | 19/20 | 0.46 |
| ▸ | JAK3 | P52333 | 19/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376492 | 0.88 | JAK2 (0.42) | JAK2JAK1JAK3EGLN2 | |
| SCHEMBL1922865 | 0.88 | JAK2 (0.42) | JAK2JAK1JAK3EGLN2 | |
| SCHEMBL2343524 | 0.85 | JAK2 (0.58) | JAK2JAK1JAK3 | |
| SCHEMBL2347429 | 0.82 | JAK2 (0.45) | JAK2JAK1JAK3 | |
| SCHEMBL376442 | 0.80 | IRAK4 (0.53) | JAK1JAK3 | |
| SCHEMBL15203451 | 0.77 | JAK2 (0.44) | JAK2JAK1JAK3 | |
| SCHEMBL2347370 | 0.77 | JAK2 (0.72) | JAK2JAK1JAK3 | |
| SCHEMBL2347372 | 0.77 | JAK2 (0.72) | JAK2JAK1JAK3 | |
| SCHEMBL376523 | 0.75 | JAK1 (0.40) | JAK2JAK1JAK3 | |
| SCHEMBL376522 | 0.75 | JAK1 (0.40) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |