Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762262 | 0.90 | HTT (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3762562 | 0.86 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3763708 | 0.83 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3766781 | 0.81 | PIK3CD (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3759310 | 0.75 | PIK3CD (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3759390 | 0.73 | PIK3CD (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3761681 | 0.73 | PIK3CD (0.54) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3759473 | 0.71 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3764745 | 0.71 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGHTT | |
| SCHEMBL3268335 | 0.71 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBHTTUBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | PIKFYVE, PI4KA, PIK3CA | PIK3CA 3/4885PIK3CD 9/4885PIK3CB 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.