Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | C1S | P09871 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylamine SCHEMBL27419090 | 0.88 | MAPT (0.57) | TSHRCYP3A4HSD17B10TDP1CYP1A2 | |
| Biphenyl-4-Amine SCHEMBL7061324 | 0.87 | CYP3A4 (0.62) | CES1SMN1; SMN2CYP3A4HSD17B10TDP1 | |
| Aniline SCHEMBL22129326 | 0.86 | TSHR (0.50) | TSHRCES1SMN1; SMN2HIF1APBRM1 | |
| Aniline SCHEMBL6049858 | 0.81 | TSHR (0.73) | TSHRCES1PBRM1CYP3A4HSD17B10 | |
| Aniline SCHEMBL8413315 | 0.81 | TSHR (0.73) | TSHRCES1PBRM1CYP3A4HSD17B10 | |
| Aniline SCHEMBL7517441 | 0.80 | TSHR (0.55) | TSHRSMN1; SMN2HIF1APBRM1CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL8845061 | 0.79 | TPMT (0.43) | CES1TDP1MAPTPTGS1 | |
| Dalfampridine SCHEMBL21084451 | 0.79 | MEN1 (0.56) | TSHRSMN1; SMN2CYP3A4TDP1CYP1A2 | |
| Naphthalene SCHEMBL29443947 | 0.79 | CES1 (0.54) | CES1SMN1; SMN2CPA1CYP1A2MAPT | |
| Biphenyl SCHEMBL27461116 | 0.79 | CES1 (0.54) | TSHRCES1SMN1; SMN2MAPTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101290307-A | Polyaniline solid phase micro- extraction head and method for making same | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2008-10-22 | — | — | CN | claimed |
| EP-1462448-B1 | Process for preparing substituted coumarins | COUNCIL SCIENT IND RES (IN) | 2006-05-10 | — | — | EP | claimed |
| EP-1462448-A1 | Process for preparing substituted coumarins | Council of Scientific and Industrial Research (IN) | 2004-09-29 | — | — | EP | claimed |
| US-6716996-B1 | POLYANILINE SALT CATALYTIC CYCLIZATION OF PHENOL AND KETO ESTER | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-04-06 | — | — | US | claimed |
| CN-117177975-B | Pyrimido [5,4, D ] pyrimidine compounds, compositions comprising the same and uses thereof | 蒙特利尔大学 | 2026-05-19 | — | — | CN | disclosed |
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
| EP-4326723-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| CN-116731045-A | KRAS inhibitor, preparation method and application thereof | 北京华森英诺生物科技有限公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022221940-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |
| EP-3966196-A1 | PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS | Grey Wolf Therapeutics Limited (GB) | 2022-03-16 | — | — | EP | disclosed |
| EP-2928902-B1 | CONJUGATE COMPOUNDS | VICTORIA LINK LTD (NZ) | 2019-07-17 | — | — | EP | disclosed |
| WO-2019058289-A1 | MAIT CELL AGONISTS | VICTORIA LINK LIMITED (NZ) | 2019-03-28 | — | — | WO | disclosed |
| EP-1462448-A1 | Process for preparing substituted coumarins | Council of Scientific and Industrial Research (IN) | 2004-09-29 | — | — | EP | disclosed |
| US-6716996-B1 | POLYANILINE SALT CATALYTIC CYCLIZATION OF PHENOL AND KETO ESTER | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-04-06 | — | — | US | disclosed |
| EP-1051424-A1 | NOVEL SYNTHONS FOR OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, INC. (US) | 2000-11-15 | — | — | EP | disclosed |
| US-6117993-A | Synthons for oligonucleotide synthesis | HYBRIDON, INC. (US) | 2000-09-12 | — | — | US | disclosed |
| EP-0836612-B1 | NOVEL SYNTHONS FOR STEREOSELECTIVE OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON INC (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999038878-A1 | NOVEL SYNTHONS FOR OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, INC. (US) | 1999-08-05 | — | — | WO | disclosed |
| EP-0836612-A1 | NOVEL SYNTHONS FOR STEREOSELECTIVE OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, Inc. (US) | 1998-04-22 | — | — | EP | disclosed |
| WO-1996037504-A1 | NOVEL SYNTHONS FOR STEREOSELECTIVE OLIGONUCLEOTIDE SYNTHESIS | HYBRIDON, INC. (US) | 1996-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NRAS, BRAF, KRAS | TSHR 2722/4885CES1 4109/4885SMN1; SMN2 3303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.