Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12702468 | 0.87 | SSTR4 (0.42) | KDM4EALDH1A1L3MBTL1FFAR4 | |
| SCHEMBL1589578 | 0.87 | SSTR4 (0.42) | KDM4EALDH1A1L3MBTL1FFAR4 | |
| SCHEMBL1589577 | 0.87 | SSTR4 (0.42) | KDM4EALDH1A1L3MBTL1FFAR4 | |
| SCHEMBL1588985 | 0.83 | FFAR4 (0.43) | CYP2C19KDM4EFFAR4 | |
| SCHEMBL12702370 | 0.83 | FFAR4 (0.43) | CYP2C19KDM4EFFAR4 | |
| SCHEMBL1588988 | 0.83 | FFAR4 (0.43) | CYP2C19KDM4EFFAR4 | |
| SCHEMBL2546557 | 0.81 | CYP2C19 (0.49) | CYP2C19POLBKDM4ESMN1; SMN2TSHR | |
| SCHEMBL2546555 | 0.81 | CYP2C19 (0.49) | CYP2C19POLBKDM4ESMN1; SMN2TSHR | |
| SCHEMBL2166026 | 0.80 | KDM4E (0.54) | POLBKDM4ESMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL17869723 | 0.80 | CYP2C19 (0.49) | CYP2C19POLBKDM4ETSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190840-A2 | CHEMICAL COMPOUNDS 979 | AstraZeneca AB (SE) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024821-A2 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |