SCHEMBL377185

SCHEMBL377185

Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CCC(=O)c1ccc(OC(C)(C)C(=O)O)cc1

nearest known ligand 0.79

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 17/20 0.79
PPARD Q03181 14/20 0.79
PPARG P37231 9/20 0.79
MAPT P10636 1/20 0.53
FFAR1 O14842 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL376650 0.88 PPARA (0.64) PPARAPPARDPPARG
SCHEMBL980030 0.85 PPARA (0.74) PPARAPPARDPPARGFFAR1
SCHEMBL4738083 0.85 PPARA (0.77) PPARAPPARDPPARG
SCHEMBL377186 0.84 PPARA (0.63) PPARAPPARDPPARG
SCHEMBL6484346 0.82 PPARA (0.68) PPARAPPARDPPARGFFAR1
SCHEMBL4678926 0.81 PPARA (0.76) PPARAPPARDPPARGFFAR1
SCHEMBL4512118 0.80 PPARA (0.59) PPARAPPARDPPARG
SCHEMBL6493966 0.80 PPARA (0.68) PPARAPPARDPPARGFFAR1
SCHEMBL4679328 0.80 PPARA (0.73) PPARAPPARDPPARGFFAR1
SCHEMBL12732549 0.79 PPARA (0.52) PPARAPPARDPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1310494-B1 PPAR (delta) ACTIVATORS NIPPON CHEMIPHAR CO (JP) 2012-01-25 EP disclosed
US-6787552-B2 HYPERGLYCEMIA, HYPERLIPIDEMIA, OBESITY, SYNDROME X; OXAZOLE OR THIAZOLE OR IMIDAZOLE DERIVATIVES NIPPON CHEMIPHAR CO., LTD. (JP) 2004-09-07 US disclosed
US-20040097739-A1 Ppar delta activators NIPPON CHEMIPHAR CO., LTD. (JP) 2004-05-20 US disclosed
EP-1310494-A1 PPAR (delta) ACTIVATORS NIPPON CHEMIPHAR CO., LTD. (JP) 2003-05-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040097739-A1 Ppar delta activators PPARD, PPARG, PPARA PPARA 3/4885PPARD 1/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.