Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4938994 | 0.98 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL250057 | 0.88 | — | — | |
| SCHEMBL11652607 | 0.87 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL74240 | 0.86 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL1746181 | 0.83 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL3984484 | 0.80 | EPHX1 (0.48) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL3867317 | 0.80 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL20929877 | 0.80 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL18531916 | 0.80 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B | |
| SCHEMBL1260402 | 0.80 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174938-A | 4-indole-2-aminopyrimidine compounds and application thereof | 浙江工业大学 | 2021-01-05 | — | — | CN | claimed |
| CN-107586279-A | A kind of new synthetic method of Gefitinib | 江苏正大清江制药有限公司 | 2018-01-16 | — | — | CN | claimed |
| CN-105503749-A | Synthetic method of 4-(3-chlorine-4-fluorophenyl)-7-methoxyl-6-[3-(4-morpholinyl) propoxy] quinazoline | NANJING EAST SUNSCREEN PHARMACEUTICAL CO LTD | 2016-04-20 | — | — | CN | claimed |
| CN-102675246-B | Preparation method of pramoxine hydrochloride | JINAN CHENGHUI SHUANGDA CHEMICAL CO LTD | 2014-04-23 | — | — | CN | claimed |
| US-6384031-B1 | — | — | None | — | — | US | disclosed |
| US-6392040-B1 | — | — | None | — | — | US | disclosed |
| CN-114685456-B | 2, 5-diketopiperazine compound derivative, preparation method thereof, pharmaceutical composition and application thereof | 大连万众益生大健康有限公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-113264889-B | Method suitable for industrial production and preparation of gefitinib | 广西师范大学 | 2023-08-08 | — | — | CN | disclosed |
| CN-113264889-B | Method suitable for industrial production and preparation of gefitinib | 广西师范大学 | 2023-08-08 | — | — | CN | disclosed |
| WO-2023088420-A1 | 1H-BENZO[B]AZEPIN-2(3H)-ONE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER | Chengdu Anticancer Bioscience, Ltd. (CN) | 2023-05-25 | — | — | WO | disclosed |
| CN-112574177-B | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2023-01-31 | — | — | CN | disclosed |
| CN-113264978-B | Novel molecular targeting anti-tumor aza steroid derivative based on lipotoxicity and preparation method and application thereof | 重庆医科大学 | 2023-01-31 | — | — | CN | disclosed |
| WO-2001044245-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | disclosed |
| CN-1278255-A | Cyclopentene derivatives useful as antagonists of the motilin receptor | ORTHO MCNEIL PHARMACEUTICAL CO (US) | 2000-12-27 | — | — | CN | disclosed |
| WO-2000068201-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |
| EP-1027342-A1 | CYCLOPENTENE DERIVATIVES USEFUL AS ANTAGONISTS OF THE MOTILIN RECEPTOR | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5972939-A | Cyclopentene derivatives useful as antagonists of the motilin receptor | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1999021846-A1 | CYCLOPENTENE DERIVATIVES USEFUL AS ANTAGONISTS OF THE MOTILIN RECEPTOR | ORTHO-MCNEIL PHARMACEUTICAL INC. (US) | 1999-05-06 | — | — | WO | disclosed |
| EP-0758315-A1 | NOVEL HYDROXIMIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | BIOREX KUTATO ES FEJLESZTÖ RT. (HU) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030649-A1 | NOVEL HYDROXIMIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | BIOREX KUTATÓ ÉS FEJLESZTO^' RT. (HU) | 1995-11-16 | — | — | WO | disclosed |