Cladribine

Cladribine

SCHEMBL3775

Nc1nc(Cl)nc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 2/20 1.00
PDE3A Q14432 2/20 1.00
PNP P00491 1/20 1.00
LMNA P02545 1/20 1.00
TP53 P04637 1/20 1.00
HTT P42858 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
RXFP1 Q9HBX9 1/20 1.00
NT5E P21589 1/20 0.67
ADORA2A P29274 2/20 0.62
ADORA3 P0DMS8 2/20 0.62
ADORA1 P30542 2/20 0.62
PDE2A O00408 1/20 0.62
ADRA1A P35348 1/20 0.62
ADRB1 P08588 1/20 0.57
DNMT1 P26358 1/20 0.57
HIF1A Q16665 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cladribine SCHEMBL2789344 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL29881889 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL11949489 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL11948325 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL4527409 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL17367349 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL7969581 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL1697053 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL21303677 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53
Cladribine SCHEMBL29355473 1.00 PDE4D (1.00) PDE4DPDE3APNPLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 97826 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
WO-2026107075-A1 METHODS OF TREATING MULTIPLE SCLEROSIS WITH CD19-CD20 DUAL CAR-T CELLS GENENTECH, INC. (US) 2026-05-21 WO claimed
US-20260138973-A1 SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE SITRYX THERAPEUTICS LTD (GB) 2026-05-21 US claimed
WO-2026107377-A1 PHARMACOLOGICAL RE-ACTIVATION OF MUTANT PVHL KARANICOLAS JOHN (US) 2026-05-21 WO claimed
US-20260137680-A1 NOVEL COMPOUNDS SITRYX THERAPEUTICS LTD (GB) 2026-05-21 US claimed
WO-2026102563-A1 DISUBSTITUTED PYRIMIDOPYRROLE ANALOG AND USE THEREOF 深圳湾实验室坪山生物医药研发转化中心 2026-05-21 WO claimed
US-20260137674-A1 COMBINATION THERAPY USING A KRAS G12D INHIBITOR, AND A NUCLEOSIDE ANALOG, AND/OR A MICROTUBULE INHIBITOR INCYTE CORP (US) 2026-05-21 US claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
EP-0364559-A4 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS 1991-01-09 EP claimed
EP-0190726-B1 NOVEL DEOXYADENOSINE PHOSPHATE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME WARNER-LAMBERT COMPANY (US) 1990-06-13 EP claimed
EP-0364559-A1 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS. SCRIPPS CLINIC RES (US) 1990-04-25 EP claimed
EP-0351795-A2 Novel deoxyadenosine compounds and methods of making and using the same WARNER-LAMBERT COMPANY (US) 1990-01-24 EP claimed
EP-0350287-A2 Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use NeXstar Pharmaceuticals, Inc. (US) 1990-01-10 EP claimed
EP-0173059-B1 METHOD FOR THE PRODUCTION OF 2'-DEOXYADENOSINE COMPOUNDS BRIGHAM YOUNG UNIVERSITY (US) 1989-11-29 EP claimed
WO-1989008658-A1 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1989-09-21 WO claimed
US-4760137-A Method for the production of 2'-deoxyadenosine compounds BRIGHAM YOUNG UNIVERSITY (US) 1988-07-26 US claimed
EP-0190726-A2 Novel deoxyadenosine phosphate compounds and methods of making and using the same WARNER-LAMBERT COMPANY (US) 1986-08-13 EP claimed
EP-0173059-A2 Method for the production of 2'-deoxyadenosine compounds BRIGHAM YOUNG UNIVERSITY (US) 1986-03-05 EP claimed