⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13037671 | 0.79 | KDM4E (0.56) | — | |
| SCHEMBL3673998 | 0.77 | KDM4E (0.54) | — | |
| SCHEMBL11748184 | 0.74 | — | — | |
| SCHEMBL22482631 | 0.74 | — | — | |
| SCHEMBL612921 | 0.74 | — | — | |
| SCHEMBL1421234 | 0.74 | — | — | |
| SCHEMBL312324 | 0.74 | — | — | |
| SCHEMBL22027752 | 0.74 | — | — | |
| SCHEMBL18428182 | 0.74 | — | — | |
| SCHEMBL26923442 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873704-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20160333017-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2016-11-17 | — | — | US | disclosed |
| US-20100331306-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-30 | — | — | US | disclosed |
| EP-0964855-B1 | PROCESS FOR PREPARING SUBSTITUTED PYRIMIDINE DERIVATIVES | LONZA AG (CH) | 2001-10-17 | — | — | EP | disclosed |
| US-6114527-A | Process for preparing substituted pyrimidine derivatives | LONZA AG (CH) | 2000-09-05 | — | — | US | disclosed |
| EP-0964855-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRIMIDINE DERIVATIVES | LONZA A.G. (CH) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998030549-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRIMIDINE DERIVATIVES | LONZA AG (CH) | 1998-07-16 | — | — | WO | disclosed |