Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378468 | 0.93 | KDR (0.45) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378418 | 0.92 | KDR (0.41) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL379085 | 0.89 | KDR (0.40) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378628 | 0.88 | KDR (0.56) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378686 | 0.88 | KDR (0.41) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378390 | 0.88 | KDR (0.48) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378307 | 0.87 | KDR (0.59) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378813 | 0.86 | KDR (0.40) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378496 | 0.86 | KDR (0.57) | KDRPLK4AURKAEPHB6RIPK2 | |
| SCHEMBL378471 | 0.86 | KDR (0.50) | KDRPLK4AURKAEPHB6RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784183-B1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER (US) | 2012-01-25 | — | — | EP | claimed |