Sugi Predict

Sugi Predict / Compounds / SCHEMBL3781494

SCHEMBL3781494

SCHEMBL3781494

COC(=O)Cn1c(=O)ccc2cc(C(F)(F)F)c(F)cc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ ALDH1A1 P00352 3/20 0.41
▸ HSD17B10 Q99714 3/20 0.41
▸ CDK4 P11802 1/20 0.39
▸ CCND1 P24385 1/20 0.39
▸ CCND2 P30279 1/20 0.39
▸ CCND3 P30281 1/20 0.39
▸ MAPK9 P45984 3/20 0.38
▸ MAPK10 P53779 2/20 0.38
▸ MAPT P10636 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ HK1 P19367 1/20 0.37
▸ HKDC1 Q2TB90 1/20 0.37
▸ MAPK8 P45983 1/20 0.36
▸ KMT2A Q03164 2/20 0.34
▸ TSHR P16473 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ PDE2A O00408 1/20 0.34
▸ KAT2B Q92831 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3781812 0.85 GRIA1 (0.38) KDM4EALDH1A1MAPK9MAPK10MAPK8
SCHEMBL29456190 0.85 GRIA1 (0.38) KDM4EALDH1A1MAPK9MAPK10MAPK8
SCHEMBL3783019 0.80 MAPK9 (0.52) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4
SCHEMBL29456293 0.80 MAPK9 (0.52) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4
SCHEMBL13100002 0.78 KDM4E (0.49) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4
SCHEMBL3780931 0.77 MAPK9 (0.51) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4
SCHEMBL13099840 0.77 KDM4E (0.48) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4
SCHEMBL3791934 0.77 MAPK8 (0.49) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4
SCHEMBL29456313 0.76 MAPK8 (0.50) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4
SCHEMBL3720936 0.76 MAPK8 (0.50) KDM4ESMN1; SMN2ALDH1A1HSD17B10CDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220081427-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2022-03-17 — — US disclosed
US-20200277285-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2020-09-03 — — US disclosed
US-20200039972-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2020-02-06 — — US disclosed
US-20190194176-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2019-06-27 — — US disclosed
US-20180319780-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2018-11-08 — — US disclosed
US-20180037577-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2018-02-08 — — US disclosed
EP-2393806-B1 INHIBITORS OF JUN N-TERMINAL KINASE ELAN PHARM INC (US) 2017-10-25 — — EP disclosed
US-9796706-B2 Inhibitors of Jun N-terminal kinase IMAGO PHARMACEUTICALS, INC. (US) 2017-10-24 — — US disclosed
US-20170107209-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2017-04-20 — — US disclosed
US-20150259330-A1 INHIBITORS OF JUN N-TERMINAL KINASE IMAGO PHARMACEUTICALS, INC. (US) 2015-09-17 — — US disclosed
US-9073891-B2 Inhibitors of Jun N-terminal kinase IMAGO PHARMACEUTICALS, INC. (US) 2015-07-07 — — US disclosed
US-8450363-B2 Inhibitors of Jun N-terminal kinase ELAN PHARMACEUTICALS, INC. (US) 2013-05-28 — — US disclosed
US-20130072494-A1 INHIBITORS OF JUN N-TERMINAL KINASE ELAN PHARMACEUTICALS, INC. 2013-03-21 — — US disclosed
US-20100331335-A1 Inhibitors of Jun N-Terminal Kinase ELAN PHARMACETICALS, INC. 2010-12-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200039972-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20190194176-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20150259330-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20170107209-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20180037577-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20130072494-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20220081427-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20200277285-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20180319780-A1 INHIBITORS OF JUN N-TERMINAL KINASE CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885
US-20100331335-A1 Inhibitors of Jun N-Terminal Kinase CHUK, MAPK6, MAPK3 KDM4E 1237/4885SMN1; SMN2 2311/4885ALDH1A1 4529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.