Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 7/20 | 0.57 |
| ▸ | WNT3A | P56704 | 7/20 | 0.57 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PIR | O00625 | 1/20 | 0.43 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19864447 | 0.91 | PRKCI (0.57) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL1726294 | 0.83 | CTNNB1 (0.61) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL875455 | 0.81 | CTNNB1 (0.67) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL31262479 | 0.81 | CTNNB1 (0.67) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL29654041 | 0.80 | PRKCI (0.63) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL8319676 | 0.80 | PRKCI (0.63) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL15969319 | 0.79 | CTNNB1 (0.68) | CTNNB1WNT3APRKCIALDH1A1HPGD | |
| SCHEMBL28709593 | 0.79 | TSHR (0.62) | CTNNB1WNT3AALDH1A1GAAHPGD | |
| SCHEMBL27312616 | 0.79 | CTNNB1 (0.57) | CTNNB1WNT3APRKCITAS1R3TAS1R1 | |
| SCHEMBL671055 | 0.79 | CTNNB1 (0.57) | CTNNB1WNT3APRKCITAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234486-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079011-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-06-25 | — | — | WO | disclosed |