Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 12/20 | 0.49 |
| ▸ | DRD2 | P14416 | 12/20 | 0.49 |
| ▸ | HTR1A | P08908 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16408968 | 1.00 | NOTUM (0.50) | NOTUMDRD3DRD2HTR1AHTR2A | |
| SCHEMBL3782375 | 1.00 | NOTUM (0.50) | NOTUMDRD3DRD2HTR1AHTR2A | |
| SCHEMBL16408948 | 1.00 | NOTUM (0.50) | NOTUMDRD3DRD2HTR1AHTR2A | |
| SCHEMBL1095555 | 0.84 | ESR1 (0.49) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL3282323 | 0.84 | ESR1 (0.49) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL3282297 | 0.84 | ESR1 (0.49) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL31121204 | 0.84 | ESR1 (0.49) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL15679204 | 0.82 | DRD3 (0.45) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL4929711 | 0.82 | ESR2 (0.53) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL15650074 | 0.82 | DRD3 (0.45) | DRD3DRD2HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331312-A1 | MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331312-A1 | MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HRH3, HRH4, HRH1 | NOTUM 683/4885DRD3 279/4885DRD2 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.