Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 20/20 | 0.77 |
| ▸ | DRD3 | P35462 | 19/20 | 0.77 |
| ▸ | DRD2 | P14416 | 15/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378370 | 1.00 | KCNH2 (0.77) | KCNH2DRD3DRD2CYP1A2 | |
| SCHEMBL378337 | 1.00 | KCNH2 (0.77) | KCNH2DRD3DRD2CYP1A2 | |
| Hydrochloric Acid SCHEMBL4436139 | 0.99 | KCNH2 (0.76) | KCNH2DRD3DRD2CYP1A2 | |
| Hydrochloric Acid SCHEMBL4563583 | 0.99 | KCNH2 (0.76) | KCNH2DRD3DRD2CYP1A2 | |
| SCHEMBL378656 | 0.87 | KCNH2 (1.00) | KCNH2DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL378536 | 0.87 | KCNH2 (0.98) | KCNH2DRD3DRD2 | |
| SCHEMBL378352 | 0.82 | DRD3 (1.00) | KCNH2DRD3DRD2CYP1A2 | |
| SCHEMBL378509 | 0.81 | DRD3 (1.00) | KCNH2DRD3DRD2CYP1A2 | |
| Hydrochloric Acid SCHEMBL397107 | 0.81 | DRD3 (0.98) | KCNH2DRD3DRD2CYP1A2 | |
| SCHEMBL3364262 | 0.81 | DRD3 (0.79) | KCNH2DRD3DRD2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2060570-B1 | Azabicyclo[3.1.0] hexane derivatives useful as modulators of dopamine D3 receptors | GLAXO GROUP LTD (GB) | 2012-01-25 | — | — | EP | claimed |