Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 10/20 | 0.64 |
| ▸ | DNMT3A | Q9Y6K1 | 6/20 | 0.64 |
| ▸ | DNMT3L | Q9UJW3 | 5/20 | 0.64 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.54 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.54 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1883263 | 0.99 | DNMT1 (0.63) | DNMT1DNMT3ADNMT3LEHMT1KMT2A | |
| Hydrochloric Acid SCHEMBL1886368 | 0.92 | MAPT (0.70) | DNMT1DNMT3ADNMT3LEHMT1KMT2A | |
| Hydrochloric Acid SCHEMBL1884373 | 0.91 | DNMT1 (0.75) | DNMT1DNMT3ADNMT3LEHMT1KMT2A | |
| SCHEMBL3656997 | 0.88 | DNMT1 (0.70) | DNMT1DNMT3ADNMT3LEHMT1KMT2A | |
| Hydrochloric Acid SCHEMBL1888905 | 0.88 | DNMT1 (0.69) | DNMT1DNMT3ADNMT3LEHMT1KMT2A | |
| SCHEMBL12240490 | 0.86 | DNMT1 (0.83) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| SCHEMBL13335888 | 0.86 | KMT2A (0.74) | DNMT1DNMT3ADNMT3LEHMT1KMT2A | |
| Hydrochloric Acid SCHEMBL1884842 | 0.86 | DNMT1 (0.82) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| Hydrochloric Acid SCHEMBL1889394 | 0.85 | DNMT1 (0.59) | DNMT1DNMT3ADNMT3LEHMT1KMT2A | |
| SCHEMBL3709576 | 0.85 | KMT2A (0.54) | DNMT1DNMT3ADNMT3LEHMT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939546-B2 | Quinoline derivatives for modulating DNA methylation | SUPERGEN, INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7790746-B2 | Quinoline derivatives for modulating DNA methylation | SUPERGEN, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20100129320-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2010-05-27 | — | — | US | disclosed |
| EP-2174938-A1 | Quinoline derivatives for modulating DNA methylation | SuperGen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20090285772-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| EP-2078008-A2 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SuperGen, Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| US-20090099106-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20090099106-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-20080175814-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2008-07-24 | — | — | US | disclosed |
| WO-2008046085-A2 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008046085-A2 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080175814-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | DNMT1 1/4885DNMT3A 2/4885DNMT3L 3/4885 |
| US-20090285772-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | DNMT1 1/4885DNMT3A 2/4885DNMT3L 3/4885 |
| US-20090099106-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | DNMT1 1/4885DNMT3A 2/4885DNMT3L 3/4885 |
| US-20100129320-A1 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | DNMT1, DNMT3A, DNMT3L | DNMT1 1/4885DNMT3A 2/4885DNMT3L 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.