Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 12/20 | 0.82 |
| ▸ | DNMT3A | Q9Y6K1 | 8/20 | 0.82 |
| ▸ | DNMT3L | Q9UJW3 | 5/20 | 0.66 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.66 |
| ▸ | MYC | P01106 | 1/20 | 0.55 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.55 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.55 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | FADS1 | O60427 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3782391 | 1.00 | DNMT1 (0.82) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| Hydrochloric Acid SCHEMBL1889349 | 0.99 | DNMT1 (0.80) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| SCHEMBL12218008 | 0.92 | DNMT1 (0.69) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| Hydrochloric Acid SCHEMBL1884707 | 0.92 | DNMT1 (0.69) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| SCHEMBL3056602 | 0.91 | DNMT1 (0.80) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| SCHEMBL3056598 | 0.91 | DNMT1 (0.80) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| SCHEMBL12218019 | 0.91 | DNMT1 (0.80) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| Hydrochloric Acid SCHEMBL3787660 | 0.91 | DNMT1 (0.80) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| Hydrochloric Acid SCHEMBL1890163 | 0.90 | DNMT1 (0.78) | DNMT1DNMT3ADNMT3LEHMT1MYC | |
| Hydrochloric Acid SCHEMBL1885374 | 0.90 | DNMT1 (0.78) | DNMT1DNMT3ADNMT3LEHMT1MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2174938-A1 | Quinoline derivatives for modulating DNA methylation | SuperGen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| EP-2078008-A2 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SuperGen, Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008046085-A2 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION | SUPERGEN, INC. (US) | 2008-04-17 | — | — | WO | disclosed |