Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 8/20 | 0.47 |
| ▸ | BACE1 | P56817 | 6/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 7/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3774885 | 0.89 | SSTR5 (0.52) | MCHR1ACHEBACE1SSTR5SIGMAR1 | |
| SCHEMBL3778586 | 0.88 | SSTR5 (0.55) | ACHEBACE1SSTR5HRH1HTR2B | |
| SCHEMBL3769684 | 0.88 | SSTR5 (0.55) | ACHEBACE1SSTR5HRH1SSTR1 | |
| SCHEMBL3776260 | 0.85 | SSTR5 (0.55) | ACHEBACE1SSTR5HRH1HTR2B | |
| SCHEMBL3780184 | 0.85 | SSTR5 (0.57) | ACHEBACE1SSTR5HRH1HTR2B | |
| SCHEMBL3782822 | 0.85 | SSTR5 (0.52) | ACHEBACE1SSTR5HRH1HTR2B | |
| SCHEMBL3780532 | 0.81 | SSTR5 (0.52) | MCHR1ACHEBACE1SSTR5HRH1 | |
| SCHEMBL2418994 | 0.80 | MCHR1 (0.46) | MCHR1SSTR5HRH1HTR2BNOS1 | |
| SCHEMBL1748525 | 0.80 | MCHR1 (0.46) | MCHR1SSTR5HRH1HTR2BNOS1 | |
| SCHEMBL3775060 | 0.78 | SSTR5 (0.49) | MCHR1ACHEBACE1SSTR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855194-B2 | Pyrimidine, quinazoline, pteridine and triazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-12-21 | — | — | US | disclosed |
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |
| CN-101405284-A | Pyrimidine, quinazoline, pteridine and derivatives | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |
| US-20070225271-A1 | Pyrimidine, quinazoline, pteridine and triazine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225271-A1 | Pyrimidine, quinazoline, pteridine and triazine derivatives | SSTR5, SSTR3, SSTR1 | MCHR1 270/4885ACHE 3332/4885BACE1 2968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.