Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.42 |
| ▸ | MTOR | P42345 | 9/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | LYN | P07948 | 3/20 | 0.38 |
| ▸ | HCK | P08631 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL9948407 | 0.89 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL9949096 | 0.81 | MTOR (0.49) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| Trifluoroacetic Acid SCHEMBL3782649 | 0.81 | MTOR (0.44) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3785561 | 0.81 | ACKR3 (0.43) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3785668 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3784964 | 0.77 | MTOR (0.54) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| Hydrochloric Acid SCHEMBL3790661 | 0.76 | MTOR (0.53) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3715483 | 0.75 | MTOR (0.53) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL9948606 | 0.74 | MTOR (0.53) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3717022 | 0.74 | MTOR (0.54) | PIK3CDPIK3CAPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | disclosed |
| EP-2398791-A1 | INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS | Amgen, Inc (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010096314-A1 | INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS | AMGEN INC. (US) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | MTOR, PIKFYVE, RICTOR | PIK3CD 8/4885PIK3CA 9/4885PIK3CB 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.