Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3335735 | 0.88 | PARP1 (0.59) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL13056839 | 0.88 | PARP1 (0.68) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL30902531 | 0.87 | PARP1 (0.67) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL29893230 | 0.83 | PARP1 (0.62) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL3339424 | 0.83 | PARP1 (0.62) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL3080392 | 0.83 | PARP1 (0.62) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL3087087 | 0.81 | PARP1 (1.00) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL3786255 | 0.80 | PARP1 (0.59) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL29965297 | 0.80 | PARP1 (0.59) | PARP1TP53AURKBAURKACSNK2A1 | |
| SCHEMBL3075555 | 0.80 | PARP1 (0.98) | PARP1TP53AURKBAURKACSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005637-A | Fused tricyclic PARP1 inhibitor, preparation method and application thereof | 上海海和药物研究开发股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117980307-A | Substituted tricyclic compounds as PARP inhibitors and application thereof | 上海瑛派药业有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115368362-A | Quinoxalinone derivatives as BTK inhibitors and application thereof | 华东理工大学 | 2022-11-22 | — | — | CN | disclosed |
| WO-2010135571-A1 | NOVEL PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010135571-A1 | NOVEL PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2010-11-25 | — | — | US | disclosed |
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2010-11-25 | — | — | US | disclosed |
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | PIM2, PIM1, PIM3 | PARP1 1573/4885TP53 315/4885AURKB 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.