Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.65 |
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | BRAF | P15056 | 9/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.58 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | PLK4 | O00444 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.58 |
| ▸ | AXL | P30530 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257980 | 0.83 | RAF1 (0.82) | RAF1EPHX2KDRBRAFMAPK14 | |
| SCHEMBL1532339 | 0.80 | RAF1 (0.77) | RAF1EPHX2KDRBRAFMAPK14 | |
| SCHEMBL15624828 | 0.79 | RAF1 (1.00) | RAF1EPHX2KDRBRAFMAPK14 | |
| SCHEMBL6929979 | 0.79 | GRM5 (0.75) | — | |
| SCHEMBL6384891 | 0.79 | RAF1 (0.78) | RAF1EPHX2KDRBRAFABL1 | |
| SCHEMBL10163311 | 0.79 | RAF1 (0.76) | RAF1EPHX2KDRBRAFMAPK14 | |
| SCHEMBL12391532 | 0.79 | RAF1 (0.76) | RAF1EPHX2KDRBRAFMAPK14 | |
| SCHEMBL6387397 | 0.78 | RAF1 (0.79) | RAF1EPHX2KDRBRAFMAPK14 | |
| SCHEMBL6473889 | 0.78 | RAF1 (0.63) | RAF1EPHX2KDRBRAFMAPK14 | |
| SCHEMBL6382351 | 0.78 | RAF1 (0.74) | RAF1EPHX2KDRBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298385-A1 | PROTEIN KINASE INHIBITORS USEFUL FOR TREATMENT OF CANCERS | DU, XIAOMIN (CN) | 2010-11-25 | — | — | US | disclosed |
| US-20100298385-A1 | PROTEIN KINASE INHIBITORS USEFUL FOR TREATMENT OF CANCERS | DU, XIAOMIN (CN) | 2010-11-25 | — | — | US | disclosed |
| US-20100298385-A1 | PROTEIN KINASE INHIBITORS USEFUL FOR TREATMENT OF CANCERS | DU, XIAOMIN (CN) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298385-A1 | PROTEIN KINASE INHIBITORS USEFUL FOR TREATMENT OF CANCERS | MAP3K6, MAP3K20, MAP3K5 | RAF1 22/4885EPHX2 3960/4885KDR 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.