Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 17/20 | 0.37 |
| ▸ | RAMP1 | O60894 | 10/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30973617 | 1.00 | CALCRL (0.37) | CALCRLRAMP1NPC1 | |
| SCHEMBL30973616 | 1.00 | CALCRL (0.37) | CALCRLRAMP1NPC1 | |
| SCHEMBL3704725 | 1.00 | CALCRL (0.37) | CALCRLRAMP1NPC1 | |
| SCHEMBL4567289 | 0.93 | NPC1 (0.35) | CALCRLRAMP1NPC1 | |
| SCHEMBL30973603 | 0.92 | CALCRL (0.37) | CALCRLRAMP1NPC1 | |
| SCHEMBL16912987 | 0.92 | CALCRL (0.35) | CALCRLRAMP1NPC1 | |
| SCHEMBL15095510 | 0.92 | CALCRL (0.35) | CALCRLRAMP1NPC1 | |
| SCHEMBL1812252 | 0.89 | CALCRL (0.38) | CALCRLRAMP1NPC1 | |
| SCHEMBL28717222 | 0.89 | CALCRL (0.38) | CALCRLRAMP1NPC1 | |
| SCHEMBL16913009 | 0.88 | CALCRL (0.32) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481556-B2 | Piperidinone carboxamide azaindane CGRP receptor antagonists | Merck, Sharp & Dohms, Corp. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20120122911-A1 | PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122911-A1 | PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, CNR2 | CALCRL 1/4885RAMP1 37/4885NPC1 908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.