Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 6/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791195 | 0.82 | DHODH (0.55) | DHODHNTRK1NTRK3NTRK2SYK | |
| SCHEMBL29997075 | 0.79 | AURKA (0.62) | NTRK1EGFRAURKAAURKBSRC | |
| SCHEMBL17666782 | 0.78 | NTRK1 (0.61) | DHODHNTRK1NTRK3NTRK2SYK | |
| SCHEMBL3774652 | 0.78 | NTRK1 (0.59) | DHODHNTRK1NTRK3NTRK2SYK | |
| SCHEMBL5740105 | 0.76 | EGFR (0.69) | EGFRABCG2TRPV1TSHRHTT | |
| SCHEMBL30379763 | 0.74 | FGFR2 (0.71) | SYKEGFRAURKAAURKB | |
| SCHEMBL30482729 | 0.74 | NTRK1 (0.75) | NTRK1NTRK3NTRK2AURKAAURKB | |
| SCHEMBL5739477 | 0.74 | EGFR (0.49) | EGFRABCG2TRPV1TSHRHTT | |
| SCHEMBL11088081 | 0.74 | EGFR (0.69) | EGFRABCG2TRPV1AURKBTSHR | |
| SCHEMBL31037444 | 0.74 | FGFR2 (0.67) | NTRK1SYKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611502-A1 | ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012030918-A1 | ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | claimed |
| WO-2010099379-A1 | JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-09-02 | — | — | WO | claimed |