Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786436 | 0.88 | KMT2A (0.55) | KDM4ESMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL20425053 | 0.86 | KDM4E (0.52) | KDM4ESMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL18255043 | 0.84 | KDM4E (0.58) | KDM4ESMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL3788594 | 0.84 | KDM4E (0.62) | KDM4ESMN1; SMN2ALDH1A1HPGDGPR119 | |
| SCHEMBL12036196 | 0.84 | KDM4E (0.46) | KDM4ESMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL19454519 | 0.83 | CYP46A1 (0.46) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL18255044 | 0.83 | KDM4E (0.57) | KDM4ESMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL3666825 | 0.83 | KDM4E (0.57) | KDM4ESMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL12071831 | 0.83 | HDAC6 (0.49) | KDM4ESMN1; SMN2KMT2AGPR119LMNA | |
| SCHEMBL18686086 | 0.82 | KDM4E (0.51) | KDM4ESMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088518-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010088518-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-08-05 | — | — | WO | disclosed |