Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 20/20 | 0.71 |
| ▸ | DRD2 | P14416 | 16/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378572 | 1.00 | DRD3 (0.71) | DRD3KCNH2DRD2CYP1A2CYP2C19 | |
| SCHEMBL12313337 | 1.00 | DRD3 (0.71) | DRD3KCNH2DRD2CYP1A2CYP2C19 | |
| SCHEMBL11911841 | 1.00 | DRD3 (0.71) | DRD3KCNH2DRD2CYP1A2CYP2C19 | |
| SCHEMBL12313333 | 0.90 | KCNH2 (0.67) | DRD3KCNH2DRD2 | |
| SCHEMBL11911839 | 0.90 | KCNH2 (0.67) | DRD3KCNH2DRD2 | |
| SCHEMBL378559 | 0.90 | KCNH2 (0.67) | DRD3KCNH2DRD2 | |
| SCHEMBL378558 | 0.90 | KCNH2 (0.67) | DRD3KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL378515 | 0.89 | KCNH2 (0.66) | DRD3KCNH2DRD2 | |
| SCHEMBL378639 | 0.88 | KCNH2 (0.68) | DRD3KCNH2DRD2 | |
| SCHEMBL11911838 | 0.88 | KCNH2 (0.68) | DRD3KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2060570-B1 | Azabicyclo[3.1.0] hexane derivatives useful as modulators of dopamine D3 receptors | GLAXO GROUP LTD (GB) | 2012-01-25 | — | — | EP | claimed |
| EP-2060570-A2 | Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors | Glaxo Group Limited (GB) | 2009-05-20 | — | — | EP | claimed |