Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | SYK | P43405 | 12/20 | 0.60 |
| ▸ | CD63 | P08962 | 5/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.55 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPKAPK5 | Q8IW41 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2475942 | 0.84 | AURKA (0.64) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL23911850 | 0.82 | AURKA (0.81) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL5239871 | 0.81 | BTK (0.54) | BTK | |
| SCHEMBL2482275 | 0.81 | AURKA (0.79) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL16295706 | 0.80 | JAK2 (0.68) | AURKASYKJAK2MAPK9MAPK10 | |
| SCHEMBL21471537 | 0.79 | AURKA (0.73) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL2477946 | 0.79 | SYK (0.69) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL2476035 | 0.79 | AURKA (0.62) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL24864097 | 0.78 | SYK (0.79) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL2482747 | 0.78 | AURKA (0.77) | AURKASYKCD63JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252617-A1 | 6-ARYL-IMIDAZ0[L, 2-A]PYRAZINE DERIVATIVES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2010-11-24 | — | — | EP | claimed |
| WO-2009102468-A1 | 6-ARYL-IMIDAZ0[L, 2-A] PYRAZINE DERIVATIVES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | claimed |