Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.55 |
| ▸ | HRH1 | P35367 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR3A | P46098 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787497 | 1.00 | DRD3 (0.55) | DRD3HRH1LMNACHRM2ADRA2A | |
| SCHEMBL3036656 | 0.87 | DRD3 (0.68) | DRD3HRH1LMNACHRM2ADRA2A | |
| SCHEMBL3036659 | 0.87 | DRD3 (0.68) | DRD3HRH1LMNACHRM2ADRA2A | |
| SCHEMBL3040906 | 0.85 | MAPK1 (0.47) | DRD3HRH1LMNACHRM2ADRA2A | |
| SCHEMBL3040904 | 0.85 | MAPK1 (0.47) | DRD3HRH1LMNACHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL3040291 | 0.83 | MAPK1 (0.52) | DRD3HRH1LMNACHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL3040296 | 0.83 | MAPK1 (0.52) | DRD3HRH1LMNACHRM2ADRA2A | |
| SCHEMBL14693553 | 0.83 | DRD3 (0.55) | DRD3HRH1LMNACHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL3043688 | 0.79 | MAPT (0.48) | LMNAMAPK1TDP1NPSR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL3043690 | 0.79 | MAPT (0.48) | LMNAMAPK1TDP1NPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243778-B1 | PIPERIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2014-10-29 | — | — | EP | disclosed |
| US-8377967-B2 | Piperidine derivative | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2013-02-19 | — | — | US | disclosed |
| US-20100331365-A1 | PIPERIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331365-A1 | PIPERIDINE DERIVATIVE | HRH4, HRH3, HRH2 | DRD3 88/4885HRH1 4/4885LMNA 4870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.