Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.73 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3156559 | 0.90 | MAOB (0.64) | MAOBSIRT2MAOARAB9AHTT | |
| SCHEMBL23327746 | 0.86 | MAOB (0.69) | MAOBSIRT2MAOARAB9AHTT | |
| SCHEMBL29795224 | 0.86 | MAOB (0.69) | MAOBSIRT2MAOARAB9AHTT | |
| SCHEMBL28627376 | 0.85 | MAOB (0.58) | MAOBSIRT2RAB9AHTTL3MBTL1 | |
| SCHEMBL25236433 | 0.85 | MAOB (0.54) | MAOBSIRT2MAOARAB9AHTT | |
| Bromide SCHEMBL28842080 | 0.85 | MAOB (0.67) | MAOBSIRT2MAOARAB9AHTT | |
| SCHEMBL28922956 | 0.81 | MAOB (0.56) | MAOBMAOARAB9AHTTL3MBTL1 | |
| SCHEMBL24628659 | 0.80 | MAOB (0.74) | MAOB | |
| SCHEMBL14966807 | 0.80 | MRGPRX4 (0.60) | MAOBKDM4EALDH1A1LMNA | |
| SCHEMBL21125443 | 0.80 | F2 (0.53) | MAOBSIRT2MAOAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016049595-A1 | HETEROARYL INHIBITORS OF PDE4 | Tetra Discovery Partners, LLC (US) | 2016-03-31 | — | — | WO | disclosed |
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |