⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1173318 | 0.64 | — | — | |
| SCHEMBL43181 | 0.62 | — | — | |
| SCHEMBL2873164 | 0.61 | — | — | |
| SCHEMBL7573764 | 0.61 | — | — | |
| SCHEMBL1644243 | 0.61 | — | — | |
| SCHEMBL3711452 | 0.61 | — | — | |
| SCHEMBL8672861 | 0.60 | — | — | |
| SCHEMBL232211 | 0.60 | — | — | |
| SCHEMBL8155627 | 0.59 | — | — | |
| SCHEMBL8155451 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658650-B2 | Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | VANDERBILT UNIVERSITY | 2014-02-25 | — | — | US | disclosed |
| US-20110319429-A1 | SUBSTITUTED 1,1,3,1-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY | 2011-12-29 | — | — | US | disclosed |
| EP-2393785-A1 | SUBSTITUTED 1,1,3,3-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | Vanderbilt University (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010088406-A1 | SUBSTITUTED 1,1,3,3-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2010-08-05 | — | — | WO | disclosed |
| EP-0113252-B1 | PROCESS FOR PRODUCING BLOCK COPOLYAMIDE | TORAY INDUSTRIES, INC. (JP) | 1991-08-07 | — | — | EP | disclosed |
| US-4507465-A | IMPACT STRENGTH | TORAY INDUSTRIES, INC. (JP) | 1985-03-26 | — | — | US | disclosed |
| EP-0113252-A2 | Process for producing block copolyamide | TORAY INDUSTRIES, INC. (JP) | 1984-07-11 | — | — | EP | disclosed |